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Milken Institute, Baszucki Brain Research Fund launch fund for bipolar disorder research

Credit: Milken Institute The Milken Institute s Center for Strategic Philanthropy and the Baszucki Brain Research Fund today announced the launch of a dedicated grant program aimed at advancing therapeutic discovery for bipolar disorder (BD). The goal is to fund research with the potential to improve treatment options for affected individuals. The Fund intends to award up to ten research grants in this cycle, providing up to $200,000 over the course of one year to support pilot research in therapeutic discovery and translational efforts. Together, these grants will amount to up to $2 million in new research dollars in the space. The Baszucki Brain Research Fund has chosen to invest in a chronically underfunded and understudied mental health condition, providing capital that would not otherwise be available to researchers, said

Brain damage caused by plasticisers

Bisphenols contained in many everyday objects can impair important brain functions in humans. Biologists from the University of Bayreuth warn of this danger in an article in Communications Biology. Their study shows that even small amounts of the plasticisers bisphenol A and bisphenol S disrupt the transmission of signals between nerve cells in the brains of fish. The researchers consider it very likely that similar interference can also occur in the brains of adult humans.

Spit samples uncover genetic risk factors for paediatric obsessive-compulsive disorder

University of Calgary and The Hospital for Sick Children (SickKids) researchers have discovered genetic risk factors for OCD that could help pave the way for earlier diagnosis and improved treatment for children and youth. Saliva samples from 5,000 kids were scanned and compared to responses using the Toronto Obsessive-Compulsive Scale. The team identified that those with a genetic variant in the gene PTPRD had a greater risk for obsessive-compulsive traits. Findings published in Translational Psychiatry.

Astrocyte cells in the fruit fly brain are an on-off switch that controls when neurons can change and grow

USC Stem Cell study reveals neural stem cells age rapidly

Credit: Albina Ibrayeva/Bonaguidi Lab In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly. There is chronological aging, and there is biological aging, and they are not the same thing, said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. We re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer s disease, epilepsy and brain injury.

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